Magnesium Supplementation

Magnesium Supplementation

Experts say it's difficult to restore a serious magnesium deficiency without supplements. Because Magnesium is essential to every bodily system, supplementing can often have profound effects. This page shows you:

  1. The main goal of a magnesium supplement: Ion delivery.
  2. The 4 categories of supplements: topical, mineral salts, & acid complexes.
  3. The 11 molecular forms of magnesium supplements. Each of these falls into one of the categories above, and has its own benefits and/or side effects.
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1. The main goal of a magnesium supplement (Ion delivery):

2. The 4 categories of supplements (topical, mineral salts, & acid complexes):

11 forms of magnesium supplements:

Magnesium Chloride - transdermal, ionic

Magnesium Orotate - heart benefits, good absorption

Magnesium Taurate - heart & brain benefits, insulin warnings

Magnesium Glycinate - calming, mood benefits

Magnesium L Threonate - mental benefits - Alzheimer's & ALS Interactions

Magnesium Sulfate - transdermal, pregnancy

Magnesium Oxide - potential absorption issues

Magnesium Malate - help fibromyalgia, potential side effects

Magnesium Hydroxide - intestinal issues

Magnesium Citrate - potentially toxic

Magnesium Aspartate & Glutamate - potentially toxic

++ Scientific References

  1. Magnesium Selective Ion Channels.
  2. The Magnesium Miracle (Revised and Updated).
  3. The structure and regulation of magnesium selective ion channels.
  4. Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial.  (While magnesium’s role in the beta cell’s actual release of insulin is less established than its role in the beta cells creating insulin, this study makes ground on the overall impact of magnesium on beta cells).
  5. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial.
  6. Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial.
  7. Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study.
  8. Magnesium orotate–experimental and clinical evidence.
  9. Magnesium orotate in myocardial and neuronal protection.
  10. Metabolic supplementation with orotic acid and magnesium orotate.
  11. Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease.
  12. Rapid recovery from major depression using magnesium treatment.
  13. Complementary vascular-protective actions of magnesium and taurine: A rationale for magnesium taurate.
  14. Magnesium taurate for the prevention and treatment of pre-eclampsia/eclampsia.
  15. Magnesium taurate and fish oil for prevention of migraine.
  16. Rapid Resolution of Chronic Back Pain with Magnesium Glycinate in a Pediatric Patient.
  17. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model.
  18. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
  19. Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α.
  20. Threonine: Are there any interactions with medications?
  22. Therapeutic Uses of Magnesium.
  23. Bioavailability of US commercial magnesium preparations.
  24. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study.
  25. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study.
  26. Proof for the Ascorbate Oxidase Activity of Ceruloplasmin.
  27. On the mechanism of citrate inhibition of ceruloplasmin ferroxidase activity.